However, little is known about whether the ABO blood group modifies an individual's response to diet. These findings demonstrate the potential importance of the ABO blood group in altering risk of disease, including cardiometabolic disease. Furthermore, group B individuals were found to have lower levels of E-selectin and a lower risk of type 2 diabetes compared to group O. Regarding cardiometabolic diseases, individuals with blood group O were found to have lower levels of von Willebrand factor (VWF) and had a reduced risk of venous thromboembolism compared to the other blood groups. As one of the first recognizable genetic variants in humans, the ABO blood group has been studied extensively for its association with a variety of diseases including cancer, ,, , malaria, and cholera. The ABO blood group is a classification of blood based on the structural variation of a certain carbohydrate antigenic substance on red blood cells. The ‘Blood-Type’ diet also proposes that lectins, which are sugar-binding proteins found in certain foods, could cause agglutination if they are not compatible with an individual's ABO blood group. Finally, individuals with an AB blood group are believed to benefit from a diet that is intermediate to those proposed for group A and group B. Following the same rationale, individuals with blood group B are considered to benefit from consumption of dairy products because this blood group was believed to originate in nomadic tribes. In contrast, those with group A should thrive on a vegetarian diet as this blood group was believed to have evolved when humans settled down into agrarian societies. Based on the ‘Blood-Type’ diet theory, group O is considered the ancestral blood group in humans so their optimal diet should resemble the high animal protein diets typical of the hunter-gatherer era. D'Adamo postulates that the ABO blood group reveals the dietary habits of our ancestors and adherence to a diet specific to one's blood group can improve health and decrease risk of chronic diseases such as cardiovascular disease. The ‘Blood-Type’ diets have gained widespread attention from the public with more than 7 million copies sold in over 60 languages, and making the New York Times bestseller list. D'Adamo in his book “ Eat Right For Your Type” published in 1996. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.Ī link between ABO blood group and diet was proposed by P.J. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: AE-S holds shares in Nutrigenomix Inc., a genetic testing company for personalized nutrition. JW is a recipient of an Ontario Graduate Scholarship. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by grant 305352 from the Advanced Foods and Materials Network (to AE-S). Received: AugAccepted: NovemPublished: January 15, 2014Ĭopyright: © 2014 Wang et al. PLoS ONE 9(1):Įditor: Nick Ashton, The University of Manchester, United Kingdom Citation: Wang J, García-Bailo B, Nielsen DE, El-Sohemy A (2014) ABO Genotype, ‘Blood-Type’ Diet and Cardiometabolic Risk Factors.

O negative blood type diet